Thursday, September 17, 2009
Will It Blend?
When I was young that's how I viewed all aspects of the body (and organisms in general.) When I touched you, you were really a kind of solid cartoon, virtually never, until I was older, providing me tactile clues as to how your body works, and what's going on under your skin. And that's for the best... given my rich confusion about far more obvious matters (and more relevant ones to a normal existence as well.)
When I touched my arm only only imagined dimly that it had anything at all to do with cells, or even muscles, really. Surface was, and to a great extent it must continue to be, everything.
For a long time I have been young enough to look at things somewhat fresh, and with a sort of naive astonishment. It is the privilege of the young to do this (though as I reminded a friend of mine, who's comments were reminding me how old we are, my privileges are running out.)
I'll never forget a wonderful drive home I had seven years ago, to Elletsville, where I lived with some punk rock kids and two little girls: Ona and Florence. I had just bought my girlfriend the new Dixie Chicks album, and had plans with her that night for her birthday. I had been working at the Bagel Bakery that morning, then come home and taken a nap and dragged myself about of bed (poor guy had to do something nice for his fetching girl...) to go to the bookstore and buy the present, then come home, clean up, and take her to dinner. Having had a cup of coffee (from the bookstore) and feeling the anticipation of her pleasure and joy at my attentions, my mind was wandering pleasantly as I turned onto Ratliff road, my road, and climbed the last hill in the whitish late afternoon sunlight of autumnal equinox.
I looked out at a hillside, for Elletsville is thick with beautiful examples, and saw the expected beauty that the late afternoon sun so regularly produces for those with the eyes to see it. Something seemed odd though. A part of my brain went back to a time in the early '90's when I noticed, while working for Orkin Pest Control, one day, that the shadows of the grass and tree's seemed doubled, or something, like an extra, dimmer sun had passed overhead. To this day I can't say exactly why it seemed like that, but I remember extremely clearly pulling into an auto body shop and asking for a welding mask to look at the sun. While waiting I punched a hole in a piece of paper and saw the image of the sun being slightly occluded by a round object, projected onto the back of my hand. The very nice proprietors of the auto body shop, fascinated to say the least by this mad bug guy, came out and gave me the mask, I glanced up at what I already had seen, then gave the mask to the proprietor, and we grinned with mutual admiration at our pipsqueak lives, full of Wheaties, work and top forties tunes, and rarely touching in any sense on the sun and the moon.
Something about the light, as I drove up that hill on Ratcliff road reminded me of that partial eclipse in the Spring of 1994. But, even as I smiled at the memory, I knew that it wasn't a change in the sun, but something about the quality of the appearance of the grass... I just looked at it one more time, and then looked across the street to the east and saw something different, something different in the appearence of that grass. Whereas the grass on the west side, between me and the sun had a kind of stained glass quality, the grass on the east side, reflecting the sun (the light of which was passing over my car and I) back into my eyes, had a buff, almost arid quality.
The grass on the western side was not reflecting light much at all, from what I could tell. "My God," I said to myself, "it's glowing." I wondered, rather dumbly, how long it had been doing that right before my eyes. So, I realized for the first time, grass accepts some percentage of light, and lets it pass right through, just like stained glass. Everywhere I looked, for about 180 degrees from the seat of my vehicle, there was, an aspect of the landscape that was not reflecting the sun, but transmitting it.
Photographers know all about the strange tricks of light, and probably know an additional thousand details about the way to look at things, when looking and choosing is your bread and butter.
But biologists and chemists and physicists know all about why things look the way they do. And in the next few posts, along with that test that you took in school about the way cells are constructed, or at least we were taught they were, I'd like to sing a little body electric, and make an even better case for the Church with the finest wrought windows: 'cus these windows were made for the sun.
Turns out that our little Test that we took of the cell is fine, if you only want to know some of the things there are to know about what's happening in a cell. Back when I was a kid, most biologists had some pretty straightforward training as to how to identify the various proteins and lipids and enzymes that made up the interior of the cell. They blended up the cell, and extracted from the smoothie what they could, then purified it, and studied it. As science has probably shown you: this method has worked marvelously. We know an astonishing amount of stuff about the nature of the molecules that comprise our bodies. It wasn't easy, but scientists have painstakingly figured a lot of our building blocks out.
There are a few details, however, that the Osterizer setting #7 (liquify) might have not helped much with. For example: what is the nature of the spaces in between the organelles and within the membrane of a cell. Typically, as a kid, I just labeled it cytoplasm, a term meant to sort of conjure the space for everything that wasn't a nucleus or organelle: I don't know, proteins, water, and the kitchen sink, or what have you. Everyone I ever talked to about it seemed to believe it was about two kitten whiskers to the side of salt water. Plus some enzymes and stuff.
And for most of my life, most people, for the most part were happy with such a picture. Painter philosophers (and half drunk art lovers) love to point out that the canvas makes a significant contribution to the mature accomplishment of a painting, and one could hardly be accused of rudeness for simply reasoning that the "white space" in a cell was sitting there keeping the rest of the cell full, and the organelles and stuff from bumping into one another.
Turns out that blending the cell (and viewing it through microscopes) gave us a ton of valuable info about its building blocks. But, like the difference between a huge pile of bricks, and a house, those building blocks had led us not only to edification: sometimes knowledge can lead you astray.
This is not to say that our understanding of cellular structure is a facile endeavor. As I said before: we have achieved incredible resolution of knowledge about all manner of aspects in Molecular Biology and even the structure of the cell. I recently read about the endoplasmic reticulum, which I am not sure it was pointed out to me as a child, is a system of three-dimensional canals and spaces involved in intracellular transport and occupying a large proportion of the cell volume. That's funny, I had thought that my cells transported nutrients through gross flows of fluid exchanged over gradients of salinity, or what have you. Canals transporting water? In a cell? I found that rather surprising. But then, after a learned a few more things, I found it, like I find mycelium, engrossingly delicious.
According to a book I am currently enjoying immensely, The Rainbow and The Worm, (The Physics of Organisms) by Mae-Wan Ho, until recently most biologists regarded the organelles of a cell to be comprised mostly of inert structural proteins, and the cytoplasm to be richly endowed with dissolved proteins and enzymes, floating randomly until plucked by the cell's metabolism for use. The exceptions to this scenario involved respiration and photosynthesis, but basically the cytoplasm was regarded as a reservoir of sorts.
Further investigation has recently shown that the proteins thought previously to be dissolved in cytoplasm, are in fact complexed into into intricate structures, throughout the "body" of the cytoplasm. These structures, while hardly well understood, are quite a shock to the old concept of storage and warehousing. The structures appear to have some use, and are thought to be in intimate contact with the hydrogen bonds of the cytoplasm water: perhaps, somewhat shockingly, meaning that the proteins play some role in structuring the watery interior of the cell. Far from being in solution (in the typical sense) they form an organized, unified structure, to accomplish some crucial role in the life of the cell. The cytoplam is a structural matrix of protein, enzyme (a type of protein) and water.
Now do you see why blending might have obscured some of the structure of the cell?
Perhaps none of this means much of anything to you. So what? you might be wondering. So their is structure to cytoplasm. "Next time I'll be sure to put some squares and triangles in the white space when I take the test on the structure of a cell. Ok, Andy?" Ok. It's a start.
Monday, September 7, 2009
A Lunar Saint

You might say this poem is about Monsanto: (it's been on the left margin of this Blog for awhile)
Sunday, September 6, 2009
The Greatest Experimentalist of All Time

I first encountered Michael Faraday in a book I read about the atmosphere, and eventually gave to my Mom (so taken with it, I was), though I'm disturbed to realize I cannot recall it's name. I want to say "Up in the Air," but that's a book about flying and airports (strange sort of throwaway book.) So I cannot remember it's name, but my mother owns it, for I bought it for her after I read it at the library.
Powdery Vines
Tuesday, September 1, 2009
Try This (at home)
A Visit To The Burne's (For The Third Time)
This is a blog post I wrote at a friends, without access to the internet, and forgot to include at it's appropriate place, in July.
Good morning heartbreak. The last few days were instructive in a millilon ways, as well as indicative to me of the gold behind a willingness to stretch beyond what I would prefer, to the new place of stasis with my friends.
I have visited Chris and Caryl Burne three times now. And while I always enjoy myself, and State College Pennsylvania, the beautiful locale that is their home, I also always see the play of the generations on a number of my friend, David's, oldest friends. And the whole is a sort of class reunion, of broken, and otherwise relatively unscarred people, coming together again.
The most remarkable would be Toonch, of Turkish extraction, but now middleaged and very much a expert of and afficianado of, American pop culture, and Jazz. It's easy to discount the guy upon aquaintence: he's as pale as a vampire, chain smoking, and staring into the distance punctuated by small bursts of contention against yourself, or perhaps merely the sunlight. Once you think of something to say, and it becomes obvious this thing is not a minor insult against Toonch, he may grant benevolence upon your choice of subject with one, perhaps two short grunts. You'd be surprised the pleasure these grunts bestow upon your person. Who can say why?
Toonch grew up with David, in State College. I forget why Toonch's parents ended up in State College for, but I suspect something related to Penn State. In any case, Toonch was alone in David's school cafeteria, repelling his fellow man, through some strategy of antisocial self expression (something to do with captive flies, go figure) and David, as repulsed as a wad of sticky gum, sat down next to the sad little guy.
In no time, I'm guessing, David was eventually regaled with Toonch's deep knowledge of esoteric subjects, especially subjects important to children, and began his fascination with the man that carried him all the way to my person so many decades later now. Those little boys, sniffing each other out, and not overwhelmed at the odor, are still inhaling now, nearly forty years on.
I could carry on about Toonch. I was not surprised to hear that his muse (name forgotten) has decided to no longer play the role she once did as curator of the Howard Stern wing of his house. As impressive as his filing system was, and as somewhat bohemian the clouds of cigarette smoke always seem to suggest, the hopeful glinting of that woman, at least, was a seriously odd contrast to the cold, dark, certitude, of a man so in need of shelter. Not in those arms, Toonch.
This would be far sadder, had one not witnessed the realm of their creation. As it was, it stood once as a vision of Toonch alone... still does. This is far less sad than it would have been were the creation truly mutual. Toonch suffered in his loss, of course, but... what's strange and delightful abount Toonch was never that woman.
There are a number of other individuals less quirky than Toonch, who brained me with the Pathos and nuance of their lives:
Chris Burne: son of a famous chess grand master, and early childhood friend of David. PHD Mathematician specializing in a few games of his own, namely game theory. Designs weapons systems for the Pentagon, and consults with Quantico once a month, on who knows what. He skipped Quantico to party with us. I guess you can skip Quantico. File that away.
Caryl Burne: Married to Chris for years now, mother to three daughters, and homemaker. Extremely quiet, perhaps introverted, it's difficult to say. The whole of her voice comes from high in her chest, in the manner of a different era of American femininity. Methinks a fair portion of this end of the register can be accounted for in her petiteness. She weaves, in their beautiful open vaulted living room (obviously constructed, by them, over time... it really is something, their house) tapestries, and other gorgeous works of textile magic. Her face quickly moves between a grin and the pausing look of a good recipient, or listener. At her age, her bone structure and figure seem to indicate that she was a hell of a beauty when young. She's still got a chin you could park a yaucht beneath, and twinkling eyes. Her pictures of her over the years, however, display a woman who never much enjoyed attracting visual attention. Three years ago, when I asked her, while walking in the small neighboring town of Fountaine, "Did you enjoy your single years? My parents in many ways never had any." She answered in the most emphatic term, "No."
"So you were glad to meet Chris?" I asked in my usual manner of pretending to not understand the simplest thing.
"I was simply so glad it was over." One of the most nuanced, and honest descriptions of happiness (for a time) I have ever heard. Hit me like a ton of bricks.
I could go on. Caryl avoided our merry, smoky, boozing band like the plague. Never once, really, do I remember her enjoying her house with us. This is, of course, very strange. It is none the less the case. Staying in her house you get the feeling that you are being endured. But, also the feeling that this woman endures much that is not accountable for, by a stranger. "Don't make assumptions," comes to mind. However glad a person might ever be, it is rarely over. Till it's over.
Last, for now, was Caroline (not her real name) wife of Carl. When I met her, it was in the yard of The Main, a sort of Union for Penn State. It was dark and some smashing Jazz musicians were playing (they had been practicing in Chris' and Caryl's basement, while we all ate upstairs, earlier in the evening.) When I first met her, she merely seemed a dark haired, middle aged woman, with a bald husband, with a quick smile, and extremely broad set eyes. Later when I saw their children her husbands eyes came back at me, incredibly wideset, and beautiful: futuristic, exotically gorgeous women.
As I was talking to Caroline it became obvious to me that one side of her face was somewhat slack, even in the dark. The next day while going to a party, which she'd be attending, David explained to me that she had suffered a stroke, at perhaps, forty five years old. She's maybe forty eight or nine.
"She was a very beautiful woman?" I asked David.
"My God," he said, "black Irish." I could see Caroine inhaibiting such a description, and fought my rising pity. At the party I made an effort to ease my discomfort deciding which eye to setle on, and redirected my probity to asking her questions, and being, how could it be otherwise, delighted by the answers of this beautiful, black Irish, mother of two gorgeous girls. She'd lived in Alaska, she'd done all manner of interesting things. We didn't get a chance to talk long enough, but my God, I felt no pity at the end. More on Caroline later.
Chris Kids:
Adrianne : Abe
Grace
Keleigh (Kee Lee)
Two of Chris kids were there: Grace and Keleigh. Keleigh is nearly thirty now, and fresh out of an investment firm, travelling the world. Highly educated with the most beautiful curving eyes, and the seemingly sad nuanced visage of her mother, but obviously ennervated in a far different fashion by the presence of her jumping jesus Dad. Quite a confection really. And I think, a killer woman. She made a number of attempts to sit with me and share conversation with a number of the extended party members. I felt a huge desire to secretly get away and have converstaions like we'd had in the past, but there was no way I was going to settle my attetnion on this gorgeous woman to the exclusion of these toddering contemporaries of my friend, David. Duh! Anyone could guess whom I'd rather be talking to, though to a certain extent, with some individuals, that was not exactly the case. But yeah, I fantasized about an extremely long night talking with Keleigh about whatever. And I have a feeling we will share a lot through Email. Sort of an ace in my fly... so to speak.
Adrianne the singing, flute playing, keyboard crashing, musician of statuesque proportions, was in L.A. trying as all of the description must, to bust through the paper target, and fall in a posture of stardom. Her fathers face, when describing her, is probably something of a burden to his other children. But you know, beauty isn't very hard to see.
Grace is a very young woman in her early twenties who seems to be just beginning in the department of adulthood. She'd fit right in in Bloomington, with her knarly hair, half shaved and knappy as all get out. But State College has it's own pantry of such delights and I've no doubt, whatsoever, "It's all good."
Not much else to say now about the trip. It was, as I knew it would be, a mixture of pleasure and pain. Though the cast of characters can't help but entertain.
